Chemical Characterization and Biological Properties Assessment of Euphorbia resinifera and Euphorbia officinarum Moroccan Propolis.

Although the plants of the genus Euphorbia are largely exploited by therapists in Morocco, the composition and antibacterial activities of propolis from these plants are still unknown. To address this gap, this study aimed to characterize the pollen type, the volatile compounds, and the phenolic and mineral profiles of three Euphorbia propolis samples collected in Morocco and evaluate their antimicrobial activities. The minimum inhibitory concentration of the propolis samples was determined by the microdilution method, and the anti-adherence activity was evaluated by the crystal violet assay. The examination of anti-quorum-sensing proprieties was performed using the biosensor Chromobacterium violaceum CV026. Pollen analysis revealed that Euphorbia resinifera pollen dominated in the P1 sample (58%), while E. officinarum pollen dominated in the P2 and P3 samples (44%). The volatile compounds were primarily composed of monoterpene hydrocarbons, constituting 35% in P1 and 31% in P2, with α-pinene being the major component in both cases, at 16% in P1 and 15% in P2. Calcium (Ca) was the predominant mineral element in both E. resinifera (P1) and E. officinarum (P2 and P3) propolis samples. Higher levels of phenols, flavonoids and dihydroflavonoids were detected in the E. officinarum P2 sample. The minimum inhibitory concentration (MIC) value ranged from 50 to 450 µL/mL against Gram-positive and Gram-negative bacteria. Euphorbia propolis displayed the ability to inhibit quorum sensing in the biosensor C. violaceum CV026 and disrupted bacterial biofilm formation, including that of resistant bacterial pathogens. In summary, the current study evidences the potential use of E. officinarum propolis (P2 and P3) to combat important features of resistant pathogenic bacteria, such as quorum sensing and biofilm formation.

Impact of lead (Pb2+) on the growth and biological activity of Serratia marcescens selected for wastewater treatment and identification of its zntR gene-a metal efflux regulator.

Microorganisms isolated from contaminated areas play an important role in bioremediation processes. They promote heavy metal removal from the environment by adsorbing ions onto the cell wall surface, accumulating them inside the cells, or reducing, complexing, or precipitating these substances in the environment. Microorganism-based bioremediation processes can be highly efficient, low-cost and have low environmental impact. Thus, the present study aimed to select Pb2+-resistant bacteria and evaluate the growth rate, biological activity, and the presence of genes associated with metal resistance. Serratia marcescens CCMA 1010, that was previously isolated from coffee processing wastewater, was selected since was able to growth in Pb2+ concentrations of up to 4.0 mM. The growth rate and generation time did not differ from those of the control (without Pb2+), although biological activity decreased in the first hour of exposure to these ions and stabilized after this period. The presence of the zntR, zntA and pbrA genes was analysed, and only zntR was detected. The zntR gene encodes a protein responsible for regulating the production of ZntA, a transmembrane protein that facilitates Pb2+ extrusion out of the cell. S. marcescens CCMA 1010 demonstrated a potential for use as bioindicator that has potential to be used in bioremediation processes due to its resistance to high concentrations of Pb2+, ability to grow until 24 h of exposure, and possession of a gene that indicates the existence of mechanisms associated with resistance to lead (Pb2+).

The relation between mandibular symphysis and the Angle class in orthodontic treatment.

Objectives: Facial perception depends on the different components of the face. The chin is a striking anatomical structure in the individual's identity and mandibular symphysis (MS) shape influences the adjacent soft tissue, determining facial harmony. In lateral cephalometry, the MS corresponds to the image of the mandibular body in its anterior curvature. It shape, inclination and thickness provide valuable information for orthodontic diagnosis and prognosis. Since facial features are associated with malocclusions, the present investigation aims to relate the height, thickness and inclination of the MS using Angle's Class. Methods: 495 lateral incidence cephalograms of an orthodontic population were analyzed using a previously developed and tested software. The sample was randomly selected and the height, thickness and inclination of the MS were measured. The values were statistically analyzed (p ≤ 0.05). Results: The distribution according to Angle's Class was 48.9% for Class I, 34.7% for Class II Division 1, 7.4% for Class II Division 2 and 8.9% for Class III. The MS height did not't show significant differences between the three dental classes. The MS thickness was significantly increased in Class II Division 2 and Class I subjects (p = 0,037). The MS inclination was significantly less in Class III subjects when compared to Class I and Class II Division 1 (p ≤ 0.001). Conclusions: The MS presented variations, which may be associated with a natural compensation against malocclusion, influencing the position of the teeth and their relationship with the other dento-craniofacial structures and with consequences on the facial harmony.

A review of plant metabolites with metal interaction capacity: a green approach for industrial applications.

Rapid industrial development is responsible for severe problems related to environmental pollution. Many human and industrial activities require different metals and, as a result, great amounts of metals/heavy metals are discharged into the water and soil making them dangerous for both human and ecosystems and this is being aggravated by intensive demand and utilization. In addition, compounds with metal binding capacities are needed to be used for several purposes including in activities related to the removal and/or recovery of metals from effluents and soils, as metals' corrosion inhibitors, in the synthesis of metallic nanoparticles and as metal related pharmaceuticals, preferably a with minimum risks associated to the environment. Plants are able to synthesize an uncountable number of compounds with numerous functions, including compounds with metal binding capabilities. In fact, some of the plants' secondary metabolites can bind to various metals through different mechanisms, as such they are excellent sources of such compounds due to their high availability and vast diversity. In addition, the use of plant-based compounds is desirable from an environmental and economical point of view, thus being potential candidates for utilization in different industrial activities, replacing conventional physiochemical methods. This review focuses on the ability of some classes of compounds that can be found in relatively high concentrations in plants, having good metal binding capacities and thus with potential utilization in metal based industrial activities and that can be involved in the progressive development of new environmentally friendly strategies.

Deep sequencing of B cell receptor repertoires from COVID-19 patients reveals strong convergent immune signatures

Deep sequencing of B cell receptor (BCR) heavy chains from a cohort of 19 COVID-19 patients from the UK reveals a stereotypical naive immune response to SARS-CoV-2 which is consistent across patients and may be a positive indicator of disease outcome. Clonal expansion of the B cell memory response is also observed and may be the result of memory bystander effects. There was a strong convergent sequence signature across patients, and we identified 777 clonotypes convergent between at least four of the COVID-19 patients, but not present in healthy controls. A subset of the convergent clonotypes were homologous to known SARS and SARS-CoV-2 spike protein neutralising antibodies. Convergence was also demonstrated across wide geographies by comparison of data sets between patients from UK, USA and China, further validating the disease association and consistency of the stereotypical immune response even at the sequence level. These convergent clonotypes provide a resource to identify potential therapeutic and prophylactic antibodies and demonstrate the potential of BCR profiling as a tool to help understand and predict positive patient responses.

Development and evaluation of a mobile application for teaching Dental Radiology / Desenvolvimento e avaliação de aplicativo móvel para ensino de Radiologia Odontológica

This study aimed to develop and evaluatea smartphone applicationwith a web content managementtoolforthe study of periapical radiographic anatomy. Design thinking activities werecarried outto better understand the proposed problem.Then, a questionnaire wasapplied via Google Formsto44 dentalstudents to assist in the development of an Appfor the teaching of radiology. Then, thebeta version of theApp was evaluated in January 2019by 51undergraduate dentalstudentsby means ofsatisfaction and usability questionnaires.The Cronbach's alpha coefficientwas applied to these questionnairesandvalues above 0.7were obtained, demonstrating theirreliability. In the evaluationof the App, which was called APPOLO,that means App of learning online, 98.04% of the students affirmed that the available contentwas certainlyimportant. The number of images wasconsidered either satisfactoryor very satisfactory by 94.19% of the participants, and 100% of them judged the qualityof theimages also satisfactoryor very satisfactory. The majority ofthe participants(94.11%)feltmotivated to complement their study using this type of methodology.The classification easy and very easy was attributed to the metricsusabilityby 98.04% of the participants, access to offered contentsby 100%of the participants, and access to the textsby 98%of the participants.The APPOLOApp provedto be practical and easy to understand, navigate, and use, as was considered a potential aid tosupport the teaching ofdental radiology students (AU).

Este estudo teve como objetivo desenvolver e avaliar um aplicativo para smartphone com uma ferramenta de gerenciamento de conteúdo da web para o estudo da anatomia radiográfica periapical. Atividades de Design Thinking foram realizadas para melhor compreender o problema proposto pelo grupo de pesquisa. Em seguida, foi realizadauma pesquisa exploratória via Google Forms com 44 estudantes de Odontologia, aplicando-se um questionário para auxiliar no desenvolvimento de um aplicativo para ensino de Radiologia. Com o aplicativo na versão inicial, beta, foram aplicados questionários de satisfação e usabilidade com 51 alunos do curso de graduação em Odontologia, para avaliação do App. O coeficiente alfa de Cronbach foi aplicado a esses questionários e valores acima de 0,7 foram obtidos, demonstrando sua confiabilidade. Na avaliação do aplicativo, denominado APPOLO, que significa "App of learning online", 98,04% dos alunos afirmaram que o conteúdo disponível era certamente importante. A quantidade de imagens foi considerada entre satisfatórias e muito satisfatórias por 94,19% dos participantes e 100% deles julgaram a qualidade das imagens também satisfatória ou muito satisfatória. A maioria dos participantes (94,11%) sentiu-se motivada em complementar seu estudo com esse tipo de metodologia. Quanto a usabilidade do aplicativo, 98,04% classificaram entre fácil e muitofácil o seu manuseio, 100% o acesso aos conteúdos ofertados e 98% o acesso aos textos, seguindo essa mesma métrica. O aplicativo APPOLO demonstrou ser prático, de fácil entendimento, navegação e utilização, e revelou auxiliar no apoio ao ensino dos alunosda disciplina de Radiologia Odontológica (AU).

Application of urea-agarose gel electrophoresis to select non-redundant 16S rRNAs for taxonomic studies: palladium(II) removal bacteria.

The 16S ribosomal RNA (rRNA) gene has been the most commonly used sequence to characterize bacterial communities. The classical approach to obtain gene sequences to study bacterial diversity implies cloning amplicons, selecting clones, and Sanger sequencing cloned fragments. A more recent approach is direct sequencing of millions of genes using massive parallel technologies, allowing a large-scale biodiversity analysis of many samples simultaneously. However, currently, this technique is still expensive when applied to few samples; therefore, the classical approach is still used. Recently, we found a community able to remove 50 mg/L Pd(II). In this work, aiming to identify the bacteria potentially involved in Pd(II) removal, the separation of urea/heat-denatured DNA fragments by urea-agarose gel electrophoresis was applied for the first time to select 16S rRNA-cloned amplicons for taxonomic studies. The major raise in the percentage of bacteria belonging to genus Clostridium sensu stricto from undetected to 21 and 41 %, respectively, for cultures without, with 5 and 50 mg/L Pd(II) accompanying Pd(II) removal point to this taxa as a potential key agent for the bio-recovery of this metal. Despite sulfate-reducing bacteria were not detected, the hypothesis of Pd(II) removal by activity of these bacteria cannot be ruled out because a slight decrease of sulfate concentration of the medium was verified and the formation of PbS precipitates seems to occur. This work also contributes with knowledge about suitable partial 16S rRNA gene regions for taxonomic studies and shows that unidirectional sequencing is enough when Sanger sequencing cloned 16S rRNA genes for taxonomic studies to genus level.

Delincuencia Juvenil y Victimización en Cabo Verde: Indicadores de Prevalencia y Caracterización

Los principales objetivos de este estudio son: (i) identificar y describir los comportamientos delictivos reportados por los jóvenes en Cabo Verde; (ii) identificar y describir las experiencias de victimización reportadas por los jóvenes en Cabo Verde; (iii) analizar si las conductas delincuentes y las experiencias de victimización difieren de acuerdo con las características socio-demográficas sexo y edad de los jóvenes. Para lograr los objetivos se encuestó a 601 jóvenes entre las edades de 12 y 21. Su participación se basó en los diferentes tipos de delitos relacionados con la conducta delincuente, así como las experiencias de victimización. De los 511 casos validados, 29% de los jóvenes admitió haber cometido algún tipo de delito contra la propiedad, 9,0% indicó haber cometido algún tipo de delito contra las personas y 18% indicó haber estado envuelto en ambos tipos de crímenes. Los resultados mostraron que son los chicos que más reportan victimización, comparativamente a las chicas. Finalmente se concluyó que los delitos más reportados por los jóvenes en Cabo Verde son los delitos cometidos contra la propiedad.

The main objectives of this study are: (i) identify and describe delinquent behaviors reported by young offenders in Cape Verde; (ii) identify and describe the victimization experiences reported by young offenders in Cape Verde; (iii) analyze whether delinquent behavior and victimization experiences differ according to socio-demographic characteristics gender and age. To accomplish the above-cited objective, 601 youths between ages 12 and 21 were surveyed. Their participation was based on the different types of crime related to delinquent behavior, as well as the experiences of victimization. Of the 511 validated cases, 29% of young people admitted having committed some sort of crime against property, 9.0% indicated having committed some sort of crime against people and, 18% indicated having been involved in both types of crimes. Results showed that boys suffered more from some type of victimization, in compression to girls who reported having been insulted via SMS/internet. Finally it was concluded that crimes against property committed by young people are those more reported in Cape Verde.

O presente estudo tem como principais objetivos: (i) identificar e descrever os comportamentos delinquentes relatados pelos jovens em Cabo Verde; (ii) identificar e descrever as experiências de vitimação relatadas pelos jovens em Cabo-Verde; (iii) analisar se os comportamentos delinquentes e as experiências de vitimação diferem em função das características sociodemográficas sexo e idade. Para tal foram inquiridos 601 jovens com idades compreendidas entre os 12 e os 21 anos, acerca da sua participação nos diferentes tipos de crime no âmbito dos comportamentos delinquentes, bem como as experiências de vitimação. Dos 511 casos validados, 29% dos jovens reconhece ter perpetrado algum tipo de crime contra a propriedade, 9.0% indica ter cometido algum tipo de crime contra as pessoas e, ainda, 18% indica ter estado envolvido em ambos os tipos de crime. Os resultados revelam que são os rapazes que mais relatam ter sofrido algum tipo de vitimação, comparativamente às raparigas que mais relatam ter sido insultadas por SMS/internet. Por fim concluiu-se que os crimes contra a propriedade são os crimes que os jovens em Cabo Verde mais relatam.

Coronal joint spaces of the Temporomandibular joint: Systematic review and meta-analysis.

INTRODUCTION: The joint space measurements of the temporomandibular joint have been used to determine the condyle position variation. Therefore, the aim of this study is to perform a systematic review and meta-analysis on the coronal joint spaces measurements of the temporomandibular joint. MATERIAL AND METHODS: An electronic database search was performed with the terms "condylar position"; "joint space"AND"TMJ". Inclusionary criteria included: tomographic 3D imaging of the TMJ, presentation of at least two joint space measurements on the coronal plane. Exclusionary criteria were: mandibular fractures, animal studies, surgery, presence of genetic or chronic diseases, case reports, opinion or debate articles or unpublished material. The risk of bias of each study was judged as high, moderate or low according to the "Cochrane risk of bias tool". The values used in the meta-analysis were the medial, superior and lateral joint space measurements and their differences between the right and left joint. RESULTS: From the initial search 2706 articles were retrieved. After excluding the duplicates and all the studies that did not match the eligibility criteria 4 articles classified for final review. All the retrieved articles were judged as low level of evidence. All of the reviewed studies were included in the meta-analysis concluding that the mean coronal joint space values were: medial joint space 2.94 mm, superior 2.55 mm and lateral 2.16 mm. CONCLUSIONS: the analysis also showed high levels of heterogeneity. Right and left comparison did not show statistically significant differences. Key words:Temporomandibular joint, systematic review, meta-analysis.

Comparison of condylar displacement between three biotypological facial groups by using mounted models and a mandibular position indicator.

OBJECTIVE: Facial-type-associated variations in diagnostic features have several implications in orthodontics. For example, in hyperdivergent craniofacial types, growth imbalances are compensated by displacement of the condyle. When diagnosis and treatment planning involves centric relation (CR), detailed knowledge of the condylar position is desirable. The present study aimed to measure condylar displacement (CD) between CR and maximum intercuspation in three facial types of an asymptomatic orthodontic population. METHODS: The study was conducted in 108 patients classified into three groups of 36 individuals each (27 women and 9 men; mean age, 20.5 years), based on the following facial patterns: hyperdivergent, hypodivergent, and intermediate. To quantify CD along the horizontal and vertical axes, the condylar position was analyzed using mounted casts on a semi-adjustable articulator and a mandibular position indicator. The Student t-test was used to compare CD between the groups. RESULTS: Vertical displacement was found to be significantly different between the hyperdivergent and hypodivergent groups (p < 0.0002) and between the hyperdivergent and intermediate groups (p < 0.0006). The differences in horizontal displacement were not significant between the groups. In each group, vertical CD was more evident than horizontal displacement was. CONCLUSIONS: All facial types, especially the hyperdivergent type, carried a significantly high risk of CD. Therefore, the possibility of CD should be carefully evaluated and considered in the assessment of all orthodontic cases in order to accurately assess jaw relationships and avoid possible misdiagnosis.

Comparison of condylar displacement between three biotypological facial groups by using mounted models and a mandibular position indicator / 대한치과교정학회지

OBJECTIVE: Facial-type-associated variations in diagnostic features have several implications in orthodontics. For example, in hyperdivergent craniofacial types, growth imbalances are compensated by displacement of the condyle. When diagnosis and treatment planning involves centric relation (CR), detailed knowledge of the condylar position is desirable. The present study aimed to measure condylar displacement (CD) between CR and maximum intercuspation in three facial types of an asymptomatic orthodontic population. METHODS: The study was conducted in 108 patients classified into three groups of 36 individuals each (27 women and 9 men; mean age, 20.5 years), based on the following facial patterns: hyperdivergent, hypodivergent, and intermediate. To quantify CD along the horizontal and vertical axes, the condylar position was analyzed using mounted casts on a semi-adjustable articulator and a mandibular position indicator. The Student t-test was used to compare CD between the groups. RESULTS: Vertical displacement was found to be significantly different between the hyperdivergent and hypodivergent groups (p < 0.0002) and between the hyperdivergent and intermediate groups (p < 0.0006). The differences in horizontal displacement were not significant between the groups. In each group, vertical CD was more evident than horizontal displacement was. CONCLUSIONS: All facial types, especially the hyperdivergent type, carried a significantly high risk of CD. Therefore, the possibility of CD should be carefully evaluated and considered in the assessment of all orthodontic cases in order to accurately assess jaw relationships and avoid possible misdiagnosis.

Diretrizes para manutenção de múltiplos órgãos no potencial doador adulto falecido: Parte III. Recomendações órgãos específicas / Guidelines for potential multiple organ donors (adult). Part III: organ-specific recommendations

A morte encefálica induz várias alterações fisiopatológicas que podem causar lesões em rins, pulmões, coração e fígado. Portanto, a atuação do intensivista durante a manutenção do potencial doador falecido exige cuidados específicos com estes órgãos visando sua maior viabilidade para transplantes. O manejo hemodinâmico cuidadoso, os cuidados ventilatórios e de higiene brônquica minimizam a perda de rins e pulmões para o transplante. A avaliação da condição morfológica e funcional do coração auxilia na avaliação do potencial transplantável deste órgão. Por fim, a avaliação da função hepática, assim como o controle metabólico e a realização de sorologias virais são fundamentais para a orientação das equipes transplantadoras na seleção do órgão a ser doado e no cuidado com o receptor.

Brain death (BD) alters the pathophysiology of patients and may damage the kidneys, the lungs, the heart and the liver. To obtain better quality transplant organs, intensive care physicians in charge of the maintenance of deceased donors should attentively monitor these organs. Careful hemodynamic, ventilatory and bronchial clearance management minimizes the loss of kidneys and lungs. The evaluation of cardiac function and morphology supports the transplant viability assessment of the heart. The monitoring of liver function, the management of the patient's metabolic status and the evaluation of viral serology are fundamental for organ selection by the transplant teams and for the care of the transplant recipient.

Diretrizes para manutenção de múltiplos órgãos no potencial doador adulto falecido: parte I. Aspectos gerais e suporte hemodinâmico / Guidelines for potential multiple organ donors (adult): part I. Overview and hemodynamic support

A desproporção entre a grande demanda por transplantes de órgãos e a baixa realização de transplantes é um grave problema de saúde pública. O reconhecimento da morte encefálica, a adequada abordagem da família e a manutenção clínica do doador falecido são fundamentais para a diminuição desta desproporção. Neste cenário, o intensivista tem importância central e a aplicação do conjunto de informações disponíveis para manutenção do potencial doador falecido está claramente associada à redução de perdas de doadores e ao aumento da qualidade e da efetivação de transplantes.

There is a relative shortage of appropriate organs available for transplantation. The appropriate diagnosis of brain death, a suitable family approach and the maintenance of the deceased donor are fundamental in addressing this issue. The intensive care physician plays a key role in the maintenance of the deceased donor, thereby reducing losses and increasing the number of successful transplants.

Diretrizes para manutenção de múltiplos órgãos no potencial doador adulto falecido: parte II. Ventilação mecânica, controle endócrino metabólico e aspectos hematológicos e infecciosos / Guidelines for potential multiple organ donors (adult): part II. Mechanical ventilation, endocrine metabolic management, hematological and infectious aspects

A atuação do intensivista durante a manutenção do potencial doador falecido na busca da redução de perdas de doadores e do aumento da efetivação de transplantes não se restringe aos aspectos hemodinâmicos. O adequado controle endócrino-metabólico é essencial para a manutenção do aporte energético aos tecidos e do controle hidro-eletrolítico, favorecendo inclusive a estabilidade hemodinâmica. A abordagem das alterações hematológicas é igualmente importante considerando as implicações da prática transfusional inapropriada. Ressalta-se ainda o papel da ventilação protetora na modulação inflamatória e conseqüente aumento do aproveitamento de pulmões para transplante. Por fim, assinala-se a relevância da avaliação criteriosa das evidências de atividade infecciosa e da antibioticoterapia na busca do maior utilização de órgãos de potenciais doadores falecidos.

The role of intensive care specialists in the maintenance of deceased potential donors is not restricted to hemodynamics. Appropriate endocrine-metabolic management is fundamental to maintaining energy support and hydroelectrolytic control, which cooperate for hemodynamic stability. Hematological changes are also important, especially considering the issues caused by inappropriate transfusions. In addition, this article discusses the role of appropriate protective ventilation to prevent inflammatory responses and to provide more transplantable lungs. Finally, judicious assessment of infections and antibiotic therapy is discussed.

Guidelines for potential multiple organ donors (adult): part I. Overview and hemodynamic support. / Diretrizes para manutenção de múltiplos órgãos no potencial doador adulto falecido: parte I. Aspectos gerais e suporte hemodinâmico.

There is a relative shortage of appropriate organs available for transplantation. The appropriate diagnosis of brain death, a suitable family approach and the maintenance of the deceased donor are fundamental in addressing this issue. The intensive care physician plays a key role in the maintenance of the deceased donor, thereby reducing losses and increasing the number of successful transplants.

Guidelines for potential multiple organ donors (adult): part II. Mechanical ventilation, endocrine metabolic management, hematological and infectious aspects. / Diretrizes para manutenção de múltiplos órgãos no potencial doador adulto falecido: parte II. Ventilação mecânica, controle endócrino metabólico e aspectos hematológicos e infecciosos.

The role of intensive care specialists in the maintenance of deceased potential donors is not restricted to hemodynamics. Appropriate endocrine-metabolic management is fundamental to maintaining energy support and hydroelectrolytic control, which cooperate for hemodynamic stability. Hematological changes are also important, especially considering the issues caused by inappropriate transfusions. In addition, this article discusses the role of appropriate protective ventilation to prevent inflammatory responses and to provide more transplantable lungs. Finally, judicious assessment of infections and antibiotic therapy is discussed.

Guidelines for potential multiple organ donors (adult). Part III: organ-specific recommendations. / Diretrizes para manutenção de múltiplos órgãos no potencial doador adulto falecido: Parte III. Recomendações órgãos específicas.

Brain death (BD) alters the pathophysiology of patients and may damage the kidneys, the lungs, the heart and the liver. To obtain better quality transplant organs, intensive care physicians in charge of the maintenance of deceased donors should attentively monitor these organs. Careful hemodynamic, ventilatory and bronchial clearance management minimizes the loss of kidneys and lungs. The evaluation of cardiac function and morphology supports the transplant viability assessment of the heart. The monitoring of liver function, the management of the patient's metabolic status and the evaluation of viral serology are fundamental for organ selection by the transplant teams and for the care of the transplant recipient.

Perfil epidemiológico dos pacientes com injúria renal aguda em uma Unidade de Terapia Intensiva / Epidemiologic profile of patients with acute kidney injury in an Intensive Care Unit

Objetivo: Descrever as características clínicas e demográficas dos pacientes internados na UTI do HU-UFSC com e sem IRA e compará-las entre esses dois grupos. Métodos: Estudo observacional e transversal aprovado pelo Comitê de Ética da UFSC. Foram coletados os dados de todos os pacientes internados por mais de 24 horas na UTI/ HU-UFSC de setembro/2007 a março/2008. A amostra foi composta por 129 pacientes obedecendo aos critérios de inclusão e exclusão. Conforme o RIFLE, os pacientes foram divididos de acordo com a apresentação de IRA. Foram analisados: a idade, o sexo, a origem do paciente, a causa da admissão, o aparelho afetado, a presença de sépsis ou choque séptico, a necessidade de VM e o uso de DVA. Utilizou-se os testes t Student e χ2, principalmente. Um p < 0,05 foi significativo. Resultados: 52 (40,3%) apresentaram IRA. Esses doentes eram mais velhos (56,4 + 18,8; p = 0,0028), apresentaram mais sépsis (17,3%; p = 0,012) e choque séptico (19,2%; p < 0,05) e usaram mais DVA (67,3%; p < 0,0001). A significância estatística foi encontrada somente para pacientes vindos da enfermaria (p = 0,02), porém, a porcentagem foi maior para aqueles oriundos da emergência e do centro cirúrgico. Conclusão: A maior média de idade, a presença de sépsis e de choque séptico e o uso de DVA foram identificados como possíveis determinantes de IRA.

Objective: To describe the clinical and demographic characteristics of patients in the Intensive Care Unit (ICU) of the Hospital Universitário from the Universidade Federal de Santa Catarina (HU-UFSC) presenting or not presenting Acute Kidney Injury (AKI) and compare them to these two groups. Methods: Observational and transversal study approved by the Ethic Committee of the Universidade Federal de Santa Catarina. The data were collected from all patients who stayed more than 24 h in ICU / HUUFSC from september/2007 to march/2008. The sample was composed by 129 patients taking into account the inclusion and exclusion criteria. Following the RIFLE criteria, the patients were divided according to the presence of IRA. The data analyzed were: age, sex, patients’ origin, cause of admission, presence of sepsis and septic shock, needs of mechanical ventilation and tuse of vasoactive drugs. It was used mainly the Student’s t and χ2 tests. A P value less than 0.05 was considered significant. Results: 52 (40.3%) presented AKI. In this group, the patients were older (56.4 + 18.8; p = 0.0028), showed more sepsis (17.3%; p = 0.012) and septic shock (19.2%; p < 0.05) and they also used more vasoactive drugs (67.3%; p < 0.0001). The statistical significance was found only for those patients who came from enfermary (p = 0.02). However, the percentage was greater for those who came from the emergency and the operating room. Conclusion: The greater age average, the presence of sepsis and septic shock and the use of vasoactive drugs were identified as the possible causes for the AKI.